3017009
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Lupus Anticoagulant Reflex Panel

LUPUS RFLX
Example Reports
Abnormal
Normal

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Specimen Collection and Handling

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Additional Technical Information

Ordering Recommendation

Use as an aid in the evaluation of unexplained prolonged partial thromboplastin time (PTT) or for patients with a significant probability of having antiphospholipid syndrome (APS). For APS, order with Cardiolipin Antibodies, IgG and IgM (0099344) and Beta-2 Glycoprotein 1 Antibodies, IgG and IgM (anti-beta2GP1) (0050321). For a list of components and reflex information, refer to the Additional Technical Information document.

New York DOH Approval Status

This test is New York state approved.

Specimen Required

Patient Preparation
Collect

Light blue (sodium citrate). Refer to Specimen Handling at aruplab.com for hemostasis/thrombosis specimen handling guidelines.

Specimen Preparation

Transfer 3 mL platelet-poor plasma to an ARUP standard transport tube. (Min: 2 mL)

Storage/Transport Temperature

CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.

Unacceptable Conditions

Serum. EDTA plasma, clotted or hemolyzed specimens.

Remarks
Stability

Ambient: 4 hours; Refrigerated: Unacceptable; Frozen at -20 C or below: 3 months

Methodology

Electromagnetic Mechanical Clot Detection/Chromogenic Assay

Performed

Sun-Sat

Reported

1-3 days

Reference Interval

Test Number
 Components
 Reference Interval
  Prothrombin Time (PT) 12.0-15.5 seconds
  PTT-LA Ratio ≤1.20
  dRVVT Screen Ratio ≤1.20
  Anti-Xa Qualitative Interpretation Not Present
  Thrombin Time (TT) ≤19.5 seconds
  Anticoagulant Medication Neutralization Not Performed
  Neutralized PTT-LA Ratio ≤1.20
  Neutralized dRVVT Screen Ratio ≤1.20
  dRVVT 1:1 Mix Ratio ≤1.20
  dRVVT Confirmation Ratio ≤1.20
  Hexagonal Phospholipid Confirmation ≤7.9

Interpretive Data



Compliance Category

Modified FDA

Note

If PTT-LA Ratio and dRVVT Screen Ratio are normal, then no further testing is performed. If either the PTT-LA Ratio or dRVVT Screen Ratio are elevated, then Anti-Xa Qualitative Interpretation is added. If PTT-LA Ratio is elevated, then Thrombin Time is also added. If Anti-Xa Qualitative Interpretation is Present and Thrombin Time is greater than 30 seconds, then Hepzyme treatment is added. If PTT-LA Ratio is Normal and Anti-Xa Qualitative Interpretation is Present, or Thrombin Time is greater than 30 seconds, and Anti-Xa Qualitative Interpretation is Not Present, or Thrombin Time is less than 30 seconds, and Anti-Xa Qualitative Interpretation is Present, then DOAC-Stop treatment is added. If either Hepzyme or DOAC-Stop treatment is added, then Neutralized PTT-LA Ratio and/or Neutralized dRVVT Screen Ratio are added. If dRVVT Screen Ratio is elevated in the absence of Hepzyme or DOAC-Stop, or if Neutralized dRVVT Screen Ratio is elevated, then dRVVT 1:1 Mix Ratio and dRVVT Confirmation Ratio are added. If PTT-LA Ratio is elevated in the absence of Hepzyme or DOAC-Stop treatment, or if Neutralized PTT-LA Ratio is elevated, then Hexagonal Phospholipid Confirmation is added. Additional charges apply.

Hotline History

View Hotline History

 

Hotline History

Date of Change
Test Name Change
Methodology
Performance/Reported Schedule
Specimen Requirements
Reference Interval
Interpretive Data
Note
CPT Code
Component Change
Other Interface Change
New Test
Inactive
08/19/2024
X
02/20/2024
X
N/A

CPT Codes

85610; 85613; 85730; if reflexed, additional CPT codes may apply: 85520; 85525; 85598; 85613; 85670; 85730.

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Components

Component Test Code* Component Chart Name LOINC
3017010 Prothrombin Time (PT) 5902-2
3017011 PTT-LA Ratio 48022-8
3017013 dRVVT Screen Ratio 15359-3
3017016 Anti-Xa Qualitative Interpretation 45274-8
3017017 Thrombin Time (TT) 3243-3
3017018 Anticoagulant Medication Neutralization 3269-8
3017019 Neutralized PTT-LA Ratio 48022-8
3017021 Neutralized dRVVT Screen Ratio 97641-5
3017023 dRVVT 1:1 Mix Ratio 75512-4
3017027 dRVVT Confirmation Ratio 50410-0
3017030 Hexagonal Phospholipid Confirmation 75883-9
3017031 Lupus Anticoagulant, Interpretation 75882-1
* Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map.

Aliases

  • Thrombin Time
  • dRVVT 1:1 Mix
  • DOAC
  • DOAC-Stop
  • DRVVT
  • Lupus Inhibitor
  • Prothrombin Time
  • PTT
  • PTT-LA Screen
  • dRVVT Confirmation
  • dRVVT Screen
  • Hexagonal Phospholipid Neutral Reflex
  • Lupus 1
  • Lupus Anticoagulant
  • Lupus Anticoagulant Comprehensive
  • Lupus Anticoagulant with Reflex to Phospholipid Neutralization
Lupus Anticoagulant Reflex Panel